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Michiaki Unno Selected Research

Immunoglobulin G (IgG)

10/2021Clinical characteristics of immunoglobulin IgG4-related sclerosing cholangitis: Comparison of cases with and without autoimmune pancreatitis in a large cohort.
3/2021Clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2020: (Revision of the clinical diagnostic criteria for IgG4-related sclerosing cholangitis 2012).
1/2014Rearranging the domain order of a diabody-based IgG-like bispecific antibody enhances its antitumor activity and improves its degradation resistance and pharmacokinetics.
10/2011In vitro and in vivo antitumor effects of recombinant bispecific antibodies based on humanized anti-EGFR antibody.
10/2008Diabody-based recombinant formats of humanized IgG-like bispecific antibody with effective retargeting of lymphocytes to tumor cells.
9/2007Highly effective recombinant format of a humanized IgG-like bispecific antibody for cancer immunotherapy with retargeting of lymphocytes to tumor cells.

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Michiaki Unno Research Topics

Disease

200Neoplasms (Cancer)
03/2024 - 08/2002
96Pancreatic Neoplasms (Pancreatic Cancer)
04/2024 - 01/2006
56Neoplasm Metastasis (Metastasis)
09/2023 - 04/2008
37Adenocarcinoma
12/2023 - 08/2011
29Carcinoma (Carcinomatosis)
12/2021 - 06/2004
22Cholangiocarcinoma
01/2021 - 11/2003
18Colorectal Neoplasms (Colorectal Cancer)
04/2024 - 01/2008
15Hemorrhage
04/2024 - 07/2011
14Neoplasms, Cystic, Mucinous, and Serous
01/2023 - 01/2007
14Inflammation (Inflammations)
05/2022 - 05/2003
14Lymphatic Metastasis
02/2022 - 04/2008
11Colonic Neoplasms (Colon Cancer)
04/2023 - 01/2008
11Rectal Neoplasms (Rectal Cancer)
12/2022 - 11/2014
10Pathologic Constriction (Stenosis)
04/2022 - 01/2011
10Stomach Neoplasms (Stomach Cancer)
10/2020 - 01/2005
9Melanoma (Melanoma, Malignant)
02/2018 - 11/2016
8Neuroendocrine Tumors (Neuroendocrine Tumor)
11/2023 - 01/2015
8Pancreatic Fistula (Pancreatic Fistulas)
11/2023 - 07/2011
8Esophageal Neoplasms (Esophageal Cancer)
09/2022 - 03/2018
8Pancreatitis
04/2022 - 01/2008
8Thrombosis (Thrombus)
03/2022 - 11/2006
8Breast Neoplasms (Breast Cancer)
04/2021 - 01/2007
7Carcinogenesis
04/2024 - 07/2011
7Head and Neck Neoplasms (Head and Neck Cancer)
02/2023 - 11/2017
7Klatskin Tumor
07/2022 - 07/2010
7Chronic Pancreatitis
02/2019 - 10/2010
6Infections
11/2023 - 11/2003
6Residual Neoplasm
06/2023 - 11/2015
6Fibrosis (Cirrhosis)
05/2023 - 01/2017
6Cholangitis
04/2023 - 09/2013
6Ulcerative Colitis
04/2023 - 08/2012
6Sclerosing Cholangitis
04/2023 - 09/2020
6Hypoxia (Hypoxemia)
03/2022 - 01/2002
6Diabetes Mellitus
06/2021 - 03/2011
5Pancreatic Intraductal Neoplasms
01/2023 - 12/2011
5Body Weight (Weight, Body)
03/2022 - 01/2013
5Esophageal Squamous Cell Carcinoma
02/2022 - 03/2018
5Hepatocellular Carcinoma (Hepatoma)
01/2022 - 11/2006
5Reperfusion Injury
07/2020 - 01/2002
4Adenoma (Adenomas)
04/2024 - 01/2007
4Hypersensitivity (Allergy)
11/2023 - 01/2007
4Liver Cirrhosis (Hepatic Cirrhosis)
10/2023 - 01/2017

Drug/Important Bio-Agent (IBA)

40GemcitabineFDA Link
09/2023 - 09/2007
31Proteins (Proteins, Gene)FDA Link
01/2023 - 01/2004
15Messenger RNA (mRNA)IBA
10/2021 - 03/2002
11EnzymesIBA
01/2024 - 07/2012
11L-methionine gamma-lyaseIBA
01/2021 - 10/2017
10MucinsIBA
12/2023 - 11/2007
10Biomarkers (Surrogate Marker)IBA
05/2023 - 09/2015
10CarbohydratesIBA
11/2022 - 05/2011
10AntigensIBA
08/2020 - 11/2013
9Glucose (Dextrose)FDA LinkGeneric
03/2024 - 05/2007
9Tumor Biomarkers (Tumor Markers)IBA
05/2023 - 11/2006
9Fluorouracil (Carac)FDA LinkGeneric
01/2023 - 10/2005
8CateninsIBA
04/2024 - 12/2010
8Methionine (L-Methionine)FDA Link
01/2021 - 10/2017
7Bile Acids and Salts (Bile Acids)IBA
04/2024 - 10/2007
7Insulin (Novolin)FDA Link
11/2023 - 01/2009
7130-nm albumin-bound paclitaxelIBA
09/2023 - 11/2017
7Paclitaxel (Taxol)FDA LinkGeneric
02/2022 - 07/2007
6Protein Isoforms (Isoforms)IBA
01/2023 - 06/2007
6Cetuximab (Erbitux)FDA Link
09/2022 - 10/2011
6Immunoglobulin G (IgG)IBA
10/2021 - 09/2007
5SteroidsIBA
05/2024 - 10/2007
5Carcinoembryonic AntigenIBA
09/2023 - 02/2017
5VimentinIBA
01/2023 - 02/2010
5Doxorubicin (Adriamycin)FDA LinkGeneric
05/2022 - 08/2005
5DNA (Deoxyribonucleic Acid)IBA
04/2022 - 07/2011
5dicarboxydine (DCD)IBA
03/2022 - 01/2018
5Cisplatin (Platino)FDA LinkGeneric
02/2022 - 10/2005
5Transcription Factors (Transcription Factor)IBA
01/2022 - 09/2008
5Adenosine Triphosphate (ATP)IBA
11/2021 - 12/2016
5Phosphotransferases (Kinase)IBA
01/2021 - 07/2014
5Small Interfering RNA (siRNA)IBA
04/2020 - 04/2008
5Temozolomide (Temodar)FDA LinkGeneric
01/2018 - 12/2016
5Cadherins (E-Cadherin)IBA
08/2015 - 04/2008
4ATP-Binding Cassette Transporters (ABC Transporters)IBA
04/2024 - 12/2016
4LigandsIBA
01/2023 - 08/2010
4Bevacizumab (Avastin)FDA Link
09/2022 - 10/2015

Therapy/Procedure

66Therapeutics
05/2024 - 01/2002
55Drug Therapy (Chemotherapy)
11/2023 - 10/2005
50Pancreatectomy
02/2024 - 01/2007
45Neoadjuvant Therapy
05/2023 - 11/2009
26Pancreaticoduodenectomy
04/2024 - 01/2007
20Hepatectomy
01/2022 - 01/2010
16Liver Transplantation
04/2024 - 09/2017
15Adjuvant Chemotherapy
12/2023 - 12/2011
12Gastrectomy
12/2022 - 01/2005
11Esophagectomy
03/2024 - 03/2018
11Chemoradiotherapy
09/2023 - 11/2017
8Lymph Node Excision (Lymph Node Dissection)
12/2022 - 11/2013
7Transplantation
05/2023 - 12/2011
7Radiotherapy
07/2022 - 10/2005
7Immunotherapy
01/2021 - 02/2003
6Islets of Langerhans Transplantation
01/2022 - 01/2012
6Stents
12/2020 - 10/2005
6Pancreaticojejunostomy
07/2020 - 10/2010
5Restorative Proctocolectomy
02/2023 - 08/2012
5Laparotomy
03/2022 - 06/2013
4Proctectomy
12/2022 - 11/2016